Androgens, andropause and neurodegeneration: exploring the link between steroidogenesis, androgens and Alzheimer's disease.
Bates KA - Cell Mol Life Sci - 01-FEB-2005; 62(3): 281-92
From NIH/NLM MEDLINE
NLM Citation ID:
15723164 (PubMed)
Full Source Title:
Cellular and Molecular Life Sciences
Publication Type:
Journal Article; Review; Review, Tutorial
Language:
English
Author Affiliation:
School of Anatomy and Human Biology, the University of Western Australia, 35 Stirling Hwy Crawley, Western Australia 6009, Australia.
Authors:
Bates KA; Harvey AR; Carruthers M; Martins RN
Number of References:
108
Abstract:
The relationship between menopause and cognitive decline has been the subject of intense research since a number of studies have shown that hormone replacement therapy could reduce the risk of developing Alzheimer's disease in women. In contrast, research into andropause has only recently begun. Furthermore, evidence now suggests that steroidogenesis is not restricted to the gonads and adrenals, and that the brain is capable of producing its own steroid hormones, including testosterone and estrogen. Sex hormones have been demonstrated to be of critical importance in the embryonic development of the central nervous system (CNS); however, we are only just beginning to understand the role that these hormones may play in the normal functioning and repair of the adult mammalian CNS. This review will summarize current research into the role of androgens and andropause on cognition and the possible mechanisms of action of androgens, with particular reference to Alzheimer's disease.
Major Subjects:
- Alzheimer Disease / * physiopathology
- Androgens / * physiology
- Andropause / * physiology
- Neurodegenerative Diseases / * physiopathology
- Steroids / * biosynthesis
Additional Subjects:
- Central Nervous System / physiology
- Cognition Disorders / physiopathology
- Female
- Humans
- Research Support, Non-U.S. Gov't
Chemical Compound Name:
(Androgens); (Steroids)