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Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men.

Woodhouse LJ - J Clin Endocrinol Metab - 01-FEB-2004; 89(2): 718-26
NLM Citation ID:
14764787 (PubMed)
Full Source Title:
Journal of Clinical Endocrinology and Metabolism
Publication Type:
Clinical Trial; Journal Article; Randomized Controlled Trial
Author Affiliation:
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.
Woodhouse LJ; Gupta N; Bhasin M; Singh AB; Ross R; Phillips J; Bhasin S
Testosterone supplementation reduces total body adipose tissue (AT), but we do not know whether the effects are uniformly distributed throughout the body or are region specific, or whether they are dose related. We determined the effects of graded doses of testosterone on regional AT distribution in 54 healthy men (18-35 yr) in a 20-wk, randomized, double-blind study of combined treatment with GnRH agonist plus one of five doses (25, 50, 125, 300, or 600 mg/wk) of testosterone enanthate (TE). Total body, appendicular, and trunk AT and lean body mass were measured by dual-energy x-ray absorptiometry, and sc, intermuscular, and intraabdominal AT of the thigh and abdomen were measured by magnetic resonance imaging. Treatment regimens resulted in serum nadir testosterone concentrations ranging from subphysiological to supraphysiological levels. Dose-dependent changes in AT mass were negatively correlated with TE dose at all sites and were equally distributed between the trunk and appendices. The lowest dose was associated with gains in sc, intermuscular, and intraabdominal AT, with the greatest percent increase occurring in the sc stores. At the three highest TE doses, thigh intermuscular AT volume was significantly reduced, with a greater percent loss in intermuscular than sc depots, whereas intraabdominal AT stores remained unchanged. In conclusion, changes in testosterone concentrations in young men are associated with dose-dependent and region-specific changes in AT and lean body mass in the appendices and trunk. Lowering testosterone concentrations below baseline increases sc and deep AT stores in the appendices and abdomen, with a greater percent increase in sc depots. Conversely, elevating testosterone concentrations above baseline induces a greater loss of AT from the smaller, deeper intermuscular stores of the thigh.
Major Subjects:

Additional Subjects:

Chemical Compound Name:
315-37-7(testosterone enanthate); 33515-09-2(Gonadorelin); 58-22-0(Testosterone)
Grant ID:
1R01AG14369 AG NIA; 1R01DK49296-05 DK NIDDK; 1R01DK59627-01 DK NIDDK; 1R01HD04338-01 HD NICHD; G12RR03026 RR NCRR; M0-00425 PHS; P20RR11145 RR NCRR; U01-DK54047 DK NIDDK; U54HD04178-01 HD NICHD; U54RR14616 RR NCRR

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