Peripheral inflammatory and fibrinolytic markers in adolescents with human growth hormone deficiency HGH-D: relation to postprandial dyslipidemia.
Lanes R - J Pediatr - 01-NOV-2004; 145(5): 657-61
From NIH/NLM MEDLINE
NLM Citation ID:
15520769 (PubMed)
Full Source Title:
Journal of Pediatrics
Publication Type:
Journal Article
Language:
English
Author Affiliation:
Pediatric Endocrine Unit, Hospital de Clinicas Caracas, Venezuela. lanes@telcel.net.ve
Authors:
Lanes R; Paoli M; Carrillo E; Villaroel O; Palacios A
Abstract:
OBJECTIVE: To determine whether peripheral inflammatory and fibrinolytic markers are elevated in growth hormone-deficient (HGHD) adolescents and associated with increased postprandial lipoproteins. STUDY DESIGN: Fifteen HGHD children on HGH treatment with a chronologic age of 12.7 +/- 2.5 years and 10 untreated HGHD adolescents with a chronologic age of 13.0 +/- 2.6 years were studied. Triglycerides (TG), C-reactive protein (CRP), fibrinogen, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) were measured in the fasting state and 4 hours after ingesting a high-fat meal; 15 healthy adolescents served as controls. RESULTS: Fasting and postprandial TG of untreated HGHD children were higher than those in treated subjects and healthy controls. Fasting TNF-alpha, CRP, and fibrinogen concentrations of untreated HGHD adolescents were higher than those in healthy controls, but similar to those of HGH-treated HGHD adolescents. Although fibrinogen levels increased after a high-fat meal in HGHD adolescents, CRP, TNF-alpha, and IL-6 concentrations did not increase further. Fasting and postprandial TG of untreated HGHD adolescents were positively associated with fasting and postprandial CRP, and with postprandial TNF-alpha and IL-6 concentrations. Fasting TG also correlated positively with fasting fibrinogen concentrations in untreated and treated HGHD adolescents. CONCLUSIONS: The pronounced inflammatory response seen in HGHD adolescents seems to be associated with the presence of elevated levels of fasting and postprandial TG, which may result in an increased susceptibility for premature atherosclerosis.
Major Subjects:
- C-Reactive Protein / * metabolism
- Fibrinogen / * metabolism
- Human Growth Hormone / * blood / * deficiency
- Interleukin-6 / * blood
- Tumor Necrosis Factor-alpha / * metabolism
Additional Subjects:
- Adolescent
- Biological Markers / blood
- Case-Control Studies
- Child
- Fasting / blood
- Female
- Humans
- Male
- Postprandial Period / physiology
- Research Support, Non-U.S. Gov't
- Triglycerides / blood
Chemical Compound Name:
(Biological Markers); (Interleukin-6); (Triglycerides); (Tumor Necrosis Factor-alpha); 12629-01-5(Human Growth Hormone); 9001-32-5(Fibrinogen); 9007-41-4(C-Reactive Protein)