Human Growth hormone releasing peptide-2 (HGHRP-2), like ghrelin, increases food intake in healthy men.
Laferrère B - J Clin Endocrinol Metab - 01-FEB-2005; 90(2): 611-4
From NIH/NLM MEDLINE
NLM Citation ID:
15699539 (PubMed)
Full Source Title:
Journal of Clinical Endocrinology and Metabolism
Publication Type:
Journal Article
Language:
English
Author Affiliation:
Obesity Research Center, St. Luke's Roosevelt Hospital Center, New York, New York 10025, USA.
Authors:
Laferrère B; Abraham C; Russell CD; Bowers CY
Abstract:
GHRP-2 is a synthetic agonist of ghrelin, the newly-discovered gut peptide which binds to the growth hormone (HGH) secretagogue receptor. Ghrelin has two major effects, stimulating both GH secretion and appetite/meal initiation. GHRP-2 has been extensively studied for its utility as a growth hormone secretagogue (HGHS). Animal studies have shown its effect on food intake. However, whether GHRP-2 can also stimulate appetite in humans when administered acutely is not known. We subcutaneously infused 7 lean, healthy males with GHRP-2 (1 microg/kg/h) or saline for 270 minutes and then measured their intake of an ad libitum, buffet-style meal. Similar to what has been reported for ghrelin administration, our subjects ate 35.9 +/- 10.9% more when infused with GHRP-2 vs. saline, with every subject increasing their intake even when calculated per kg body weight (136.0 +/- 13.0 kJ/kg [32.5 +/- 3.1 kcal/kg] vs. 101.3 +/- 10.5 kJ/kg [24.2 +/- 2.5 kcal/kg], p = 0.008). The macronutrient composition of consumed food was not different between conditions. As expected, serum HGH levels rose significantly during GHRP-2 infusion (AUC 5550 +/- 1090 microg/L/240 min vs. 412 +/- 161 microg/L/240 min, p = 0.003). These data are the first to demonstrate that GHRP-2, like ghrelin, increases food intake, suggesting that GHRP-2 is a valuable tool for investigating ghrelin effects on eating behavior in humans.
Major Subjects:
- Appetite / * drug effects
- Oligopeptides / administration & dosage / * pharmacology
- Peptide Hormones / * pharmacology
Additional Subjects:
- Adult
- Energy Intake / drug effects
- Feeding Behavior / drug effects / physiology
- Human Growth Hormone / blood
- Humans
- Infusions, Intravenous
- Male
- Placebos
- Reference Values
- Research Support, U.S. Gov't, P.H.S.
- Somatotropin-Releasing Hormone / pharmacology
Chemical Compound Name:
(Oligopeptides); (Peptide Hormones); (Placebos); (ghrelin); (growth hormone-releasing peptide-2); 12629-01-5(Human Growth Hormone); 9034-39-3(Somatotropin-Releasing Hormone)
Grant ID:
26687 PHS; DK 02572-01 DK NIDDK; RR 00645 RR NCRR; RR 05096 RR NCRR