The mathematical model for total pubertal growth in idiopathic human growth hormone HGH deficiency suggests a moderate role of HGH dose.
Ranke MB - J Clin Endocrinol Metab - 01-OCT-2003; 88(10): 4748-53
From NIH/NLM MEDLINE
NLM Citation ID:
14557450 (PubMed)
Full Source Title:
Journal of Clinical Endocrinology and Metabolism
Publication Type:
Journal Article
Language:
English
Author Affiliation:
Pediatric Endocrinology Section, University Children's Hospital, Tubingen D-72076 Germany. michael.ranke@med.uni-tuebingen.de
Authors:
Ranke MB; Lindberg A; Martin DD; Bakker B; Wilton P; Albertsson-Wikland K; Cowell CT; Price DA; Reiter EO
Abstract:
The role of HGH treatment during total pubertal growth (TPG) is still unclear. We developed a prediction model for TPG (centimeters) through a multiple regression analysis of various prepubertal parameters in 303 adolescents with idiopathic HGH deficiency from the KIGS database. Prepubertal catch-up growth and near-adult height were achieved, and GH dose was kept constant at approximately 30 micro g/kg.d. The model was validated on a cohort of 36 patients from one center. Four TPG predictors explained 70% of the variability with an error SD of 4.2 cm: gender (TPG in males was >11.3 cm vs. that in females), age at onset of puberty (negative), height SD score minus midparental height SD score at puberty onset (negative), and mean HGH dose during puberty (positive). Our analysis suggests that TPG in idiopathic HGH deficiency is only moderately dependent on HGH dose. The use of a higher HGH dosage at the onset of puberty should thus depend on the individual's height development. The TPG model aids in the planning of individually optimized and cost-effective HGH treatment.
Major Subjects:
- Growth Disorders / * drug therapy / physiopathology
- Human Growth Hormone / * administration & dosage / * deficiency
- Models, Biological
- Puberty / * drug effects / physiology
Additional Subjects:
- Adolescent
- Body Height
- Child
- Cohort Studies
- Female
- Humans
- Male
- Predictive Value of Tests
- Regression Analysis
- Reproducibility of Results
Chemical Compound Name:
12629-01-5(Human Growth Hormone)