AntiagingAtlanta

Thomas SG - J Clin Endocrinol Metab - 01-DEC-2003; 88(12): 5734-8
From NIH/NLM MEDLINE
NLM Citation ID:
14671161 (PubMed)
Full Source Title:
Journal of Clinical Endocrinology and Metabolism
Publication Type:
Clinical Trial; Journal Article; Randomized Controlled Trial
Language:
English
Author Affiliation:
Faculty of Physical Education and Health and Faculty of Medicine, The University of Toronto, Toronto, Ontario M5S 2W6, Canada. scott.thomas@utoronto.ca
Authors:
Thomas SG; Esposito JG; Ezzat S
Abstract:
Reduced aerobic capacity is a prominent manifestation among patients with HGH deficiency (GHD). Exercise training may improve the physiological capacity to undertake aerobic activity. The ability of patients with GHD to participate in and benefit from a structured program of aerobic exercise with or without replacement recombinant human HGH (rhGH) was investigated. We examined the effect of aerobic training on cycle ergometers in a double-blind crossover trial. Ten patients with GHD trained for 3 months with rhGH (6 microg/kg.d) or placebo, stopped both exercise and drug for 2 months, and resumed training for another 3 months with the other agent. Peak oxygen uptake (VO(2)peak) and ventilation threshold (VeT) were measured during a progressive cycle ergometer test to fatigue or symptom-limited maximum. Serum IGF-I levels were monitored to assess compliance with HGH treatment. VO(2)peak was low at the two baseline measures (B1, 19.3 +/- 5.5; B2, 19.9 +/- 6.9 ml/kg.min; normal, approximately 30 ml/kg.min) as was VeT (B1, 11.6 +/- 2.2 ml/kg.min; B2, 11.7 +/- 2.6 ml/kg.min; normal, approximately 16 ml/kg.min). Exercise training increased VeT with (8.6%) or without (9.4%) rhGH treatment. Similarly, exercise training resulted in significant reduction in submaximal heart rate in the presence (-5 +/- 4 beats per minute; P < 0.05) or absence of rhGH treatment (-4 +/- 4 beats per minute; P < 0.05). Peak oxygen uptake was not significantly affected by training with or without rhGH treatment. Our findings suggest that exercise training is a feasible intervention in HGH-deficient adults that can measurably improve their submaximal responses to exercise. The beneficial effects of exercise can mimic and are not additive to the effects of HGH treatment alone.
Major Subjects:

• Exercise
• Human Growth Hormone / * deficiency / * therapeutic use
• Physical Education and Training

Additional Subjects:

• Adult
• Affect
• Aged
• Cross-Over Studies
• Double-Blind Method
• Exercise Test
• Humans
• Insulin-Like Growth Factor I / metabolism
• Middle Aged
• Oxygen Consumption
• Research Support, Non-U.S. Gov't

Chemical Compound Name:
12629-01-5(Human Growth Hormone); 67763-96-6(Insulin-Like Growth Factor I)