Testosterone Replacement Therapy TRT Hormone

by Dr. Randy Smith of Antiaging Atlanta

Alternatives to TRT Testosterone Replacement Therapy HRT Hormone Replacement Therapy


2017 Nov 23. pii: S2050-0521(17)30122-1. doi: 10.1016/j.sxmr.2017.09.004. [Epub ahead of print]

Alternatives to Testosterone Therapy: A Review.



Although testosterone therapy (TTh) is an effective treatment for hypogonadism, recent concerns regarding its safety have been raised. In 2015, the US Food and Drug Administration issued a warning about potential cardiovascular risks resulting from TTh. Fertility preservation is another reason to search for viable alternative therapies to conventional TTh, and in this review we evaluate the literature examining these alternatives.


To review the role and limitations of non-testosterone treatments for hypogonadism.


A literature search was conducted using PubMed to identify relevant studies examining medical and non-medical alternatives to TTh. Search terms included hypogonadism, testosterone replacement therapy, testosterone therapy, testosterone replacement alternatives, diet and exercise and testosterone, varicocele repair and testosterone, stress reduction and testosterone, and sleep apnea and testosterone.


Review of peer-reviewed literature.


Medical therapies examined include human chorionic gonadotropins, aromatase inhibitors, and selective estrogen receptor modulators. Non-drug therapies that are reviewed include lifestyle modifications including diet and exercise, improvements in sleep, decreasing stress, and varicocele repair. The high prevalence of obesity and metabolic syndrome in the United States suggests that disease modification could represent a viable treatment approach for affected men with hypogonadism.


These alternatives to TTh can increase testosterone levels and should be considered before TTh. Lo EM, Rodriguez KM, Pastuszak AW, Khera M. Alternatives to Testosterone Therapy: A Review. Sex Med Rev 2017;X:XXX-XXX.

Copyright © 2017. Published by Elsevier Inc.


Aromatase Inhibitors; Human Chorionic Gonadotropin; Selective Estrogen Receptor Modulator; Testosterone; Testosterone Therapy; Varicocele

  Personal Message from Dr. Smith

My primary goal at AntiagingAtlanta is to enhance your quality of life through providing a comprehensive approach to antiaging medicine.

I am committed to providing you with the best Antiaging Medicine program available.

Call me today and schedule your Antiaging Medicine evaluation.


Dr. Randy Smith



Antiaging Atlanta
12600 Deerfield Parkway
Suite 100
Alpharetta, Georgia 30004

Phone: 678-566-3602

Call today today and speak with Dr. Smith to schedule your personal Agntiaging Medicine evaluation.

Getting Started

To unsubscribe to our newsletter email Dr. Smith at:

Dr. Smith