Hormone Replacement Therapy

by Dr. Randy Smith of Antiaging Atlanta

Testosterone Hormone Replacement Therapy improves quality of life in older men with LOH.

 2017 May;49(4). doi: 10.1111/and.12630. Epub 2016 Jul 8.

Testosterone replacement therapy improves health-related quality of life for patients with late-onset hypogonadism: a meta-analysis of randomized controlled trials.

Nian Y1, Ding M1, Hu S1, He H2, Cheng S1, Yi L1, Li Y1, Wang Y1.


Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late-onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta-analysis of randomized controlled trials on this issue. Five randomized controlled trials total 1,212 patients were included. Fixed-effect model was used to calculate the weighted mean difference of score of Aging Males' Symptom rating scale. Our result reveals that testosterone replacementtherapy improves patients' health-related quality of life in terms of the decrease in the AMS total score [WMD = -2.96 (-4.21, -1.71), p < .00001] and the psychological [WMD = -0.89 (-1.41, -0.37), p = .0008], somatic [WMD = -0.89 (-1.41, -0.37), p = .0008] and sexual [WMD = -1.29 (-1.75, -0.83), p < .00001] subscale score.


Aging Males' Symptom rating scale; health-related quality of life; late-onset hypogonadism; testosterone deficiency; testosteronereplacement therapy

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